Both books

DNA Computing / Reference

Glossary

Appendix B4 min890 wordsMarkdown source

Artificial general intelligence. There is no universally accepted test. This book treats AGI as a research target requiring broad, transferable capability, not as a label for the current DOGMA model.

Research Bench

Turn an idea into a result another student can reproduce

A disciplined lab separates an interesting story from a scientific contribution.

Question

Specify

Write a narrow claim that an experiment can refute.

H0 / H1
AGI

Artificial general intelligence. There is no universally accepted test. This book treats AGI as a research target requiring broad, transferable capability, not as a label for the current DOGMA model.

Allosteric routing

A DOGMA hypothesis in which a small set of selected sites broadcasts non-local context. It is inspired by distant regulatory effects in proteins but implemented as ordinary digital computation.

Archive

A collection of reproducible candidate checkpoints retained for scientific diversity. Archive membership is weaker than production promotion.

Attention

A learned weighted aggregation over items, usually produced from queries, keys, and values. The canonical DOGMA research line does not use self-attention.

Base

In biology, one of the nucleobases represented by \(A,C,G,T\) in DNA. In DOGMA, “base” may also name a typed digital symbol; the two meanings must not be confused.

Byte-level model

A sequence model whose basic vocabulary is encoded bytes rather than words, subwords, codons, or nucleotides.

Candidate

A trained descendant checkpoint together with its architecture, data manifest, lineage, and evaluation evidence.

Canonical DOGMA

The currently governed non-transformer implementation: overlapping local memory, causal transcript computation, regulation, and declared optional recurrence or bounded memory.

Central dogma

The biological framework describing major classes of sequence-information transfer among DNA, RNA, and protein [Crick1970]. It is not the claim that information only flows in one everyday-language direction.

Checkpoint

A serialized model state, configuration, and associated training metadata.

Codon

A three-nucleotide sequence interpreted during biological translation. DOGMA may use codon-inspired groupings digitally; these are not cellular translation.

Cross-entropy

Average negative log probability assigned to correct targets.

DNA computing

Physical computation using DNA molecules and biochemical reactions. This is distinct from running a DNA-inspired neural network on conventional hardware.

DNABERT

A transformer family trained on DNA sequence representations. It is a baseline for genomic machine learning, not a wet-lab DNA computer.

DOGMA

DNA-Organized Genomic Model Architecture, a MapleAI research family exploring genome-inspired organization and non-transformer sequence computation.

Epigenetic memory

A bounded persistent-state mechanism inspired by biological regulation without sequence change. The analogy does not imply biological epigenetics is being simulated faithfully.

Evaluation leakage

Any path by which held-out examples or their answers influence training, selection, or prompt design in a way not declared by the protocol.

Evolutionary search

Optimization through variation and selection among candidates. In DOGMA it operates above gradient-based parameter training.

Fitness

A metric or vector of metrics used to compare candidates. A proxy fitness can be gamed and must not be confused with the complete research goal.

GenBank

The public nucleotide-sequence database maintained by the U.S. National Center for Biotechnology Information and partners.

Genome

The complete hereditary material of an organism. In DOGMA, “prompt genome” or “model genome” is an explicit engineering analogy for a versioned, heritable configuration.

Gradient descent

Optimization that changes parameters in the direction of decreasing differentiable loss.

Held-out set

Data excluded from training and used for validation or testing under a declared selection policy.

Hermon DNA

A separate MapleAI/Hermon domain model line for practical DNA assistance. It must not be confused with DOGMA architecture research.

Homology-aware split

A data split designed to keep strongly related biological sequences in the same partition, reducing over-optimistic evaluation.

Lineage

The recorded parent-child relationships among candidate checkpoints and their mutations.

MAP-Elites

A quality-diversity algorithm that retains the highest-performing candidate in each behavior cell [Mouret and Clune2015].

Model collapse

Degradation that can occur when generations of models train recursively on generated approximations that replace or distort the original data distribution [Shumailov et al.2024].

Mutation

A declared change from parent to candidate. Ordinary DOGMA cycles mutate one bounded training variable.

Non-transformer

An architecture without transformer layers. The canonical DOGMA contract also forbids self-attention; not every non-transformer model makes that stronger choice.

Pareto dominance

A relation where one candidate is no worse on every objective and better on at least one.

Perplexity

The exponential of average cross-entropy. It measures next-symbol uncertainty under a fixed tokenization and dataset.

Phenotype

An organism’s observable traits. DOGMA uses the term metaphorically for realized model behavior.

Population-based training

A method that trains a population while adapting hyperparameters by replacing weak members with mutated descendants of stronger members [Jaderberg et al.2017].

Promotion

The controlled act of making an evaluated checkpoint the live model.

Quality-diversity

Search that seeks a collection of high-quality but behaviorally different solutions instead of one global solution.

Real-data anchor

A training record tied to an audited external observation rather than generated solely by a model in the recursive loop.

Recurrence

Sequence computation that updates and carries a state from one position to the next.

Recursive learning

A governed process in which a system proposes, trains, and evaluates descendants. It does not mean unrestricted online rewriting.

Reverse complement

The sequence obtained by reversing a DNA strand and replacing each base with its complement \(A\leftrightarrow T\), \(C\leftrightarrow G\).

Self-attention

Attention where queries, keys, and values are derived from the same sequence.

State-space model

A sequence model based on transitions of an internal state. Modern selective state-space models can be input-dependent and efficiently scanned.

Synthetic data

Examples generated or transformed by an algorithm rather than directly observed. Provenance matters more than whether an example looks realistic.

TetraMemory

DOGMA’s overlapping fixed-width local memory representation. Its claimed benefits require ablation and matched-baseline evidence.

Transformer

A neural architecture built around attention, residual pathways, and feed-forward blocks [Vaswani et al.2017].